I'm pretty confident that that's from Sen to chihiro no kamikakushi, more commonly known as Spirited away. Unfortunately it's not a Anime, rather a feature length animated film.
Fan art, nothing else. It borrows some of the elements of Mushishi and Japanese culture but yeah, just an artwork.
Yeah
No.
http://myanimelist.net/character/8298/Kaonashi
Kaonashi No Face is an odd spirit that takes an interest in Chihiro. Chihiro lets No Face into the bathhouse through a side door. At first, he is a strange, cloaked, masked wraith that merely breathes and smiles. No Face is a lonely being who seems to sustain itself on the emotions of those he encounters, particularly their emotional reception to his gifts. He is helpful to Chihiro because she helped him, whereas after observing the bathhouse staff's reaction to gold and his own attempts to win them over with more gold, he reacts to their greed by becoming a grotesque monster which eats lots of food and some of the staff. He calms down and reverts to his former state after he leaves the bathhouse's influence. At the end, he stays with Zeniba as a helper. No Face's mask, movement, and name share many similarities with the Japanese Noh theater. He also assumes the voice(s) and personality of those he "eats".